Inhibition of growth and induction of apoptosis in PC3 and A549 cell lines by hydro alcoholic fruit extract of Morinda tinctoria roxb: in vitro analysis
نویسنده
چکیده
The present study aimed to investigate the effect of hydroalcoholic extract of Morinda tinctoria Roxb fruit on inhibition of growth and induction of apoptosis in human prostate carcinoma cells (PC-3) and lung carcinoma (A549) cells. Morinda tinctoria Roxb hydro alcoholic fruit extract (MTHFE) was taken to in vitro studies, like phytochemical screening, MTT assay, cell induced apoptosis. Dose dependant cytotoxic activities were exhibited by PC-3 cell lines and A549 cells. The result showed that, as the dose of the extract increased, the no of viable cells were found to be decreased, which confirms the anti-cancer and cytotoxic activities of the fruit extract.
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